Assessment the role of Interferon Lambda in Regulating Immune Response in SLE Disorder

Abstract

          The role of interferons in modulating immune responses following infections or various danger signals is a crucial one, as they belong to a class of powerful antiviral cytokines. The first description of Type III interferons, known as IFNλs, was that they are a distinct mechanism that prevents viral replication at epithelial barrier sites and reduces inflammation. type III interferons have a complicated impact on both the innate and adjustive immune systems and may also have a detrimental impact on systemic autoimmune disorders. Respective autoimmune conditions such as arsenic general lupus erythematosus bear been associated with elevated levels of IFNλs in the blood and tissues of individuals and those levels are connected to particular clinical manifestations and lab findings. This review aims to difficultly assess the existing literature on the biology of IFNλs and explore their potential contribution to immune dysregulation and tissue injury in SLE diseases. This article review the new advances of the literature along the orderly look of interferons lambda and their receptor in association SLE.