Investigating the Role of LH, FSH, AMH, and TGF-B Gene Expression in Polycystic Ovary Syndrome

Abstract

Polycystic ovarian syndrome (PCOS) is one of the most prevalent endocrine disorders in reproductive-age women, with prevalence 10 – 18 % according to diagnostic criteria. Women'slifeare impacted by polycystic ovary syndrome, particularly while trying to conceive. The focus of this research is to establish a connection between polycystic ovary syndrome (PCOS) and the aforementioned variables (LH, FSH, and AMH) and to quantify the impact of transforming growth factor gene expression on PCOS. Eighty women, ranging in age from nineteen to forty-five, were part of the study; thirty of these women had polycystic ovarian syndrome, and thirty of these women had delayed childbearing. The other twenty women were healthy. The hormone levels was analyzed after separating the serum. To determine gene expression, blood samples were collected using a Trizol tube and RT PCR was used for analysis. In conclusion from the results in comparison to control women, those with delayed childbearing had lower levels of TGF-β expression, and the results demonstrated a rise in AMH and LH levels without a change in FSH levels.